Active aldehydes drive T cell exhaustion in the tumor microenvironment, finds study

Cancer immunotherapy is a type of cancer treatment that harnesses the immune system to fight cancer cells. The treatment ...
EurekAlert!

Activated CD8+ T cells enable early prediction and precision treatment of acute graft‑versus‑host disease

Acute graft-versus-host disease (aGVHD) is a life-threatening complication after allogeneic hematopoietic stem cell ...
eLife

HIV-specific CD8+ T-cell proliferative response 24 weeks after early antiretroviral therapy initiation is associated with the subsequent reduction in the viral reservoir

In individuals who started antiretroviral therapy during acute HIV infection, the proliferative capacity of HIV-specific CD8+ ...
Science Daily

Atherosclerosis: How immune cells migrate into plaques

CD8+ T cells accumulate in atherosclerotic plaques. Researchers identify a crucial signaling pathway -- with therapeutic potential. CD8+ T cells accumulate in atherosclerotic plaques. LMU researchers ...
News Medical

Granzyme K+ CD8+ T-cells identified as key drivers of recurrent airway inflammation

Study uncovers a pathogenic subset of memory T-cells that promote tissue inflammation and highlights a potential target for treating nasal polyps and other inflammatory airway diseases. Study: ...
The American Journal of Managed Care

Clonally Expanded CD8+ T Cells May Play Role in Alopecia Areata

Clonally expanded CD8+ T cells are key drivers of alopecia areata, mediating epithelial cell death and immune infiltration. JAK inhibitors are approved for AA treatment, but recurrence is common, ...
News Medical

CD4 T cells found to be key players in tuberculosis defense

The researchers concluded that the interplay between CD4 and CD8 T cells creates an anti-inflammatory environment that is hostile to Mtb and, as a result, limits bacterial growth and disease severity.