G protein-coupled receptors (GPCRs) are seminal transducers of extracellular signals into intracellular responses, orchestrating intricate cascades that regulate cell proliferation, migration and ...
Scientists from the UNC School of Medicine have developed a new tool for studying a key process in cells called G-protein signaling, which plays a central role in the normal functioning of cells and ...
Heterotrimeric G proteins, comprising Gα, Gβ and Gγ subunits, are central to the transduction of extracellular signals into precise intracellular responses in plants. These proteins not only regulate ...
A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled ...
Infectious diseases are illnesses caused by pathogenic microorganisms—including viruses, bacteria, fungi, and parasites—that invade a host, replicate, and ...
The novel biosensor technology used in this study can also be transferred to other so-called G protein-coupled receptors (GPCRs), which act as crucial “signal receivers” in our cells and are of major ...
Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results ...
A paper published in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key driver in ...
To stay healthy, our cells rely on a self-cleaning mechanism that removes defective or unnecessary components. This process, ...