Gene expression is controlled, in part, by the interactions between genes and regulatory elements located along the genome.

Gene expression is controlled, in part, by the interactions between genes and regulatory elements located along the genome. Those interactions depend ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

Genetic activity underlies biological functions, so organisms have to make sure that the right genes are expressed at the ...

A study shows epigenetic proteins regulate genes through diverse dynamic patterns, not simple on-off control, with each ...

National Eye Institute (NEI) scientists have found that the way the retina metabolizes glucose directly controls which genes get switched on and off in light-sensing photoreceptors. The findings ...

To help achieve more precise control of gene therapy, engineers have designed a new control circuit that can keep gene expression levels within a target range. The method could be used to deliver ...

About RSwitch RSwitch is a proprietary regulatable gene therapy system that enables oral, small molecule drug control of transgene levels in gene and cell therapy applications. RSwitch encodes a ...

A figure from the paper illustates a key finding of "compromised compartmentalization": chromatin that was locking genes down in health became more open in Alzheimer's, while chromatin that was open ...

National Eye Institute researchers have uncovered how glucose metabolism in the retina influences gene expression in photoreceptors, offering new potential targets for age-related macular degeneration ...