The mechanism of cooperativity in the human hemoglobin tetramer (a dimer of αβ dimers) has historically been modeled as a simple two-state system in which a low-affinity structural form (T) switches, ...

Oligomerization of transcription factors controls their translocation into the nucleus and DNA-binding activity. Here we present a fluorescence microscopy analysis termed pCOMB (pair correlation of ...

NAD(H) and NADP(H) are important electron carriers in cellular metabolism that also act as essential cofactors for a range of enzymes involved in various biological processes. Nicotinamide adenine ...

A depiction of the newly discovered Y-shape (tripartite) at the center of myocilin, a protein commonly studied in hereditary glaucoma. It is a dimer of dimers and a tetramer of coiled coils and the ...

More than half of human cancers involve mutations in the p53 tumor-suppressor gene, specifically in its DNA-binding core domain, pointing to this region of the p53 protein as being pivotal to its anti ...

The S100 family is a set of dimeric, calcium-binding proteins which have been seen to be over expressed in several types of cancer. S100 proteins attach to the Cterminal region (293-393) of p53, the ...