This transgenic mouse model expresses a floxed ATPase type 13A2 (Atp13a2) gene, with loxP sites flanking exons 2 to 3 (The Jackson Laboratory). The ATP13A2 protein is a transmembrane lysosomal ATPase ...
The APOE Christchurch mutation attenuated amyloid pathology in the brains of mice who had received intracerebral injections of AD tau fibrils. Plaque pathology was evaluated using the fluorescent dye ...
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