As the main surface receptors that connect cells to the extracellular matrix (ECM), integrins control cell adhesion and migration — the fundamental cell behaviours that underlie development, immune ...

Integrins are major cell surface receptors for the extracellular matrix (ECM). Intracellularly, integrins link to the actin cytoskeleton and signalling systems and thus function as mechanochemical ...

A team of researchers, led by scientists at the Queen Mary University of London, has made a breakthrough in our understanding of how cancer cells are able to spread around the body and form deadly new ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused immense suffering and economic hardship to millions of people worldwide. To date, the mechanism of infection by SARS-CoV-2 ...

Researchers from the US and China summarize the role of integrins in cancer cells and the current status of anti-integrin therapy for cancer Globally, human hepatocellular carcinoma (HCC) is the sixth ...

In a recent study posted to the medRxiv* pre-print server, a team of researchers demonstrated the inhibitory action of integrin/transforming growth factor beta 1 (TGF-β1) inhibitor GLPG0187 on severe ...

Help is on the way for overactive bladder or incontinence. According to new research the epithelium, a layer of cells lining the bladder's surface, senses bladder fullness through proteins called ...

Integrins are heterodimeric (αβ) cell surface receptors that are potential therapeutic targets for a number of diseases. Despite the existence of structural data for all parts of integrins, the ...

Newly unveiled startup Morphic Therapeutic hopes that it’s solved some of the technical challenges that have hindered integrin-targeting therapeutics. It’s got more insight into their mechanism of ...

Initial clinical experience with the first-in-class anti-metastasis therapeutic TTX-MC138. A phase 1 study of LB4330, a peptide fused to CLDN18.2 antibody targeting the tumor antigen associated (TAA) ...

Protein evolution occurs slowly via small incremental mutations—usually. However, dramatic changes can happen: for instance, a fragment of one protein getting copied into the middle of another. While ...