CpG density and epigenetic modification state modulate DNA mechanics, altering its intrinsic compatibility with nucleosome formation.

Eukaryotes possess promoter and termination regions that are largely nucleosome free. Nucleosomes are positioned at canonical distances from the transcription start site (TSS). In Saccharomyces ...

Tokyo, April 14 - A research group led by Hitoshi Kurumizaka, a professor of structural biology at Waseda University, unveiled the crystal structure of an overlapping dinucleosome, a newly discovered ...

Individual cells divide through a process called mitosis, during which the cell's copied DNA is separated between two resulting daughter cells. Despite recent advances in cell biology, the mechanism ...

Researchers at the University of California San Diego say they have identified a key factor that partially unravels nucleosomes and thus opens the way for genes to activate. The identification of NDF, ...

Researchers at The University of Texas MD Anderson Cancer Center have shown that DNA inflexibility, or rigidity, inside the nucleosome regulates the positioning of INO80. This highlights that the ...

Reconstructed image of the basic unit of chromatin, the nucleosome. Nucleosomes link together like beads on a string, connected by stretches of linker DNA. To form a condensate, these strings bind ...