Psychiatric and neurodevelopmental disorders may arise from anomalies in long-range neuronal connectivity downstream of pathologies in dendritic spines. However, the mechanisms that may link spine ...

Ever since mammalian adult neurogenesis was confirmed, scientists had hoped to get pluripotent cells of the subventricular zone (SVZ) to become something other than olfactory bulb neurons when they ...

In Fragile X syndrome (FXS), the most common cause of autism, sensory signals from the outside world are integrated differently, causing them to be underrepresented by cortical pyramidal neurons in ...

Unlike peripheral nervous system neurons and certain groups of nerve cells in the CNS, cortical projection neurons are tolerant of axonal lesions. This resistance is incongruent with the massive death ...

Scientists have used precious and rare access to live human cortical tissue to identify functionally important features that make human neurons unique. This experimental work is among the first of its ...

In Fragile X syndrome, sensory signals from the outside world are integrated differently, causing them to be underrepresented by cortical pyramidal neurons in the brain, according to a new study. In ...

Results of a new study led by Roberto Araya, a Canadian neuroscientist, biophysicist and researcher at the CHU Sainte-Justine Research Centre, in Montreal, show that in Fragile X syndrome (FXS), the ...

The cerebral cortex processes sensory information via a network of neural connections. But how are these signals adjusted to refine our perceptions? A team from the University of Geneva (UNIGE) has ...

Scientists have zeroed in on a certain set of cortical neurons as instigators of a toxic circuit in a mouse model of TDP-43 proteinopathy. Somatostatin interneurons amp up their activity when the mice ...