Thirty Japanese clinical isolates of Mycobacterium tuberculosis were analysed by pyrazinamide susceptibility testing and pyrazinamidase assay, as well as polymerase chain reaction for single-strand ...

For patients with multidrug-resistant tuberculosis (TB), taking at least six potentially effective drugs, particularly including pyrazinamide, significantly increased the likelihood of achieving a ...

Clinical Infectious Diseases publishes clinically relevant articles on the pathogenesis, clinical investigation, medical microbiology, diagnosis, immune mechanisms, and treatment of diseases caused by ...

A recent study has identified a new mechanism for PZA-resistance, which provides new insight into the how this mysterious drug works. Pyrazinamide (PZA) -- a frontline tuberculosis (TB) drug -- kills ...

Global challenges regarding the treatment of multidrug drug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) include factors related to their diagnosis and ...

MANY substances have been used in the treatment of tuberculosis with the supposition that the resistance of the patient to the disease might be enhanced. Of these, gold salts and tuberculin were the ...

Patients who have drug-resistant tuberculosis (TB) have a similar microbiological response to bedaquiline-based second-line medications as patients with drug-sensitive TB taking first-line regimens, ...

It takes a combination of drugs to beat TB back The first new medication in half a century for the widespread treatment of tuberculosis has also shown the potential to cure drug-resistant TB. While ...

Patients who have drug-resistant tuberculosis (TB) have a similar microbiological response to bedaquiline-based second-line medications as patients with drug-sensitive TB taking first-line regimens, ...