CWRU has a decades-long history of research into pyruvate dehydrogenase complex deficiency (PDCD). The pyruvate dehydrogenase complex (PDC) is a multiple enzyme complex in the shape of a pentagonal ...

The dehydrogenase complexes serve as pivotal regulators in cellular metabolism, orchestrating key oxidative reactions within the tricarboxylic acid (TCA) cycle and beyond. These multi‐enzyme ...

Lung cancer, notorious for its high mortality rates, is a leading cause of cancer-related deaths globally, with metastasis being the primary contributor to poor patient outcomes. A critical factor in ...

Cancer cells are known to favor aerobic glycolysis for energy production, a phenomenon termed the Warburg effect. This metabolic shift is essential for tumor growth, supplying energy, metabolites, and ...

FDA grants a Type A meeting on December 18th to review new and expanded datasets submitted by Saol to help identify a feasible path forward without the need for an additional clinical trial ROSWELL, ...