Schematic diagram of the IL-6/JAK/STAT3 signaling pathway activation in mouse liver macrophages. IRs, inhibitory receptors (IRs); ICIs, immune checkpoint inhibitors; IL-6, interleukin-6; ALT, alanine ...
Triple-negative breast cancer (TNBC) lacks hormone receptors and HER2 amplification, limiting the effectiveness of targeted therapies and contributing to its aggressive clinical behavior. As aberrant ...
Support cells in the brain called astrocytes (green) increase their levels of STAT3 activation (pSTAT3, magenta) in a mouse model of dementia. This promotes changes in gene expression and inflammation ...
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