Numerous studies support a role of phosphatase and tensin homolog deleted from chromosome 10 (Pten) as a tumor suppressor gene that controls epithelial cell homeostasis to prevent tumor formation.

Squamous cell carcinoma (SCC) is a lethal cancer arising from the stratified epithelia of skin, esophagus, cervix, as well as the head and neck tissues. Genomic analysis of SCCs identified genomic ...