How actin wavefronts rescue T cell receptors from endocytosis

Every time our body encounters a new disease-causing agent, a crucial defense system called adaptive immunity comes into play ...
Medscape

CAR-T Cells and Beyond: Breakthroughs and Challenges Ahead

Chimeric antigen receptor (CAR)-T cells and T-cell therapies have been used in the treatment of various cancers for several years. In a review published in JAMA, a research team led by Christian ...
ascopubs.org

Distinct outcomes with the detection of endemic Burkitt lymphoma, T-cell receptor (TCR) complementarity determining region-3s (CDR3s) matching known anti-HIV TCR CDR3s.

Secondary primary malignancies (SPMs) with CAR-T cell therapy in RR-DLBCL from real-world data. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include a ...
GEN

Computationally Designed Receptors Help Engineered T Cells Control Tumors

Scientists at École Polytechnique Fédérale Lausanne (EPFL), and at UNIL-CHUV, University Hospital Lausanne (CHUV) and University of Lausanne (UNIL) have developed a computational method to create ...