Shenglin Mei of Virginia Tech's Fralin Biomedical Research Institute was part of a multi-institutional team including researchers from Harvard Medical School, Massachusetts General Hospital, the ...
Reversing treatment resistance in prostate cancer: Study solves longstanding puzzle in tumor biology
Scientists at the Herbert Irving Comprehensive Cancer Center (HICCC) have discovered a key mechanism that makes prostate cancer cells resistant to the latest drugs used to treat them. Their findings, ...
A new AI tool, AAnet, has discovered five distinct cell types within tumors, offering a deeper look into cancer's inner diversity. This insight could transform how we treat cancer, enabling more ...
Chimeric antigen receptor T (CAR-T) cell therapy has revolutionized hematologic cancer treatment, but its efficacy in solid tumors remains limited by poor infiltration into the complex tumor ...
It is perhaps no surprise that preclinical cancer models that fail to consider the TME show limited success in therapeutic development. Subcutaneous cell line-derived xenograft (CDX) models, in which ...
Circulating tumor cells were first described in 1869 by Thomas Ashworth, an Australian pathologist who observed them in a peripheral blood sample taken from a patient with metastatic cancer. 1 They ...
The tumor microenvironment is not just a site of cancer growth—it is a high-stakes metabolic contest where tumor and immune cells vie for limited resources. Amino acids, once seen as passive nutrients ...
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