A fact sheet about the BRCA1 and BRCA2 genes, what to do if a person tests positive for alterations in one of these genes, and consequences of genetic testing.

Studies have shown that BRCA1 mutations are not random, but under adaptive selection, indicating that although BRCA1 mutations are linked to breast cancer, the mutations likely have a beneficial effect …

Learn how BRCA1 mutations impact hereditary breast cancer risk and how BRCA1-associated breast cancers can be treated with therapies like PARP inhibitors.

Inheriting damaged copies of the BRCA1 or BRCA2 genes can increase the risk for breast cancer and ovarian cancer in women and the risk for breast and prostate cancer in men, as well as other cancers.

Jul 22, 2025 · An inherited BRCA1 mutation increases your risk for certain cancers, including breast and prostate cancer. Learn about testing, prevention, and treatment.

Dec 23, 2025 · Harmful changes in the genes can increase the risk of cancer. Healthcare professionals sometimes call these gene changes variants or mutations. The BRCA gene test looks for changes in …

Apr 1, 2025 · Women with a BRCA1 or BRCA2 mutation who overcome their breast cancer with treatment appear to have a higher-than-average chance of developing a second cancer. This is …

It is important to understand that having a BRCA1 or BRCA2 mutation does not mean that a person will develop cancer; it only means that they have an increased risk. Women who have a BRCA1 or …

Mutations in the BRCA1 gene are associated with an increased risk of breast cancer in both men and women, as well as several other types of cancer. These mutations are present in every cell in the …

Women without a BRCA mutation have around a 1%-2% chance of developing ovarian cancer in their life. Women with a BRCA1 mutation have around a 40% chance. Women with the BRCA2 mutation …