It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor -α (CBFα). RUNX proteins form a heterodimeric complex with CBFβ which confers …

The RUNX family of transcription factors, including RUNX1, RUNX2, and RUNX3, are key regulators of development and can function as either tumor suppressors or oncogenes in cancer.

Jul 23, 2025 · RUNX proteins are a family of “runt-related transcription factors” encoded by three different genes in mammals: RUNX1, RUNX2, and RUNX3. They are considered master regulators …

Nov 14, 2025 · RUNX1 is a transcription factor that forms a complex with the cofactor CBFB. This complex provides stability to the RUNX1 protein which is involved in the generation of hematopoietic …

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The RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). Like other transcription factors, the RUNX1 protein attaches (binds) to specific regions of …

Aug 6, 2021 · Runx is an evolutionary conserved family of transcription factors (TFs) that are best known for their roles in the regulation of the expression of genes involved in embryonic development and …

Abstract | RUNX proteins belong to a family of metazoan transcription factors that serve as master regulators of development. They are frequently deregulated in human cancers, indicating a...

Apr 7, 2023 · The RUNX family of transcription factors, including RUNX1, RUNX2, and RUNX3, are key regulators of development and can function as either tumor suppressors or oncogenes in cancer.

Mar 2, 2024 · Runt-related transcription factors (RUNX) are a family of transcription factors that are essential for normal and malignant hematopoietic processes. Their most widely recognized role in …