TGF-β signaling in health, disease and therapeutics
Mar 22, 2024 · The dysfunction of TGF-β can play key roles in many diseases, and numerous targeted therapies have been developed to rectify its pathogenic activity.
TGF-β Signaling in Health and Disease - PMC
Defects of TGF-β signaling, particularly in epithelial cells, tissue fibroblasts, and immune cells, disrupt immune tolerance, promote inflammation, underlie the pathogenesis of fibrosis and …
TGF-β signaling in health and disease - ScienceDirect
Sep 14, 2023 · Defects of TGF-β signaling, particularly in epithelial cells, tissue fibroblasts, and immune cells, disrupt immune tolerance, promote inflammation, underlie the pathogenesis of …
TGF-β and macrophages in the rise and fall of inflammation
However, imbalance between the proinflammatory properties and immunosuppressive activities of TGF-β can result in chronic states of inflammation and fibrosis.
TGF-β: Master regulator of inflammation and fibrosis
Oct 4, 2018 · TGF-β causes a profound inhibition of the anti-inflammatory effects of glucocorticoids in the epithelium. The underlying signalling pathways proved elusive, with …
TGF-beta Receptor: Its Function in Health and Disease
Jul 24, 2025 · TGF-beta can suppress inflammation and influence the differentiation and function of various immune cells, including T cells and macrophages. This broad influence on cell …
Role of TGF-Beta and Smad7 in Gut Inflammation, Fibrosis and ...
Indeed, studies in animals and humans have shown that defects in TGF-β1 production and/or signaling can lead to the development of immune-inflammatory pathologies, fibrosis and …