Feb 17, 2025 · In addition, bempedoic acid and statin combination therapy can be used for patients sensitive to high statin doses. 6 Diagram of how bempedoic acid inhibits cholesterol synthesis within …

Bempedoic acid is a lipid-lowering agent pivotal in managing patients with elevated low-density lipoprotein cholesterol (LDL-C) levels. The U.S. Food and Drug Administration (FDA) has sanctioned …

Jul 1, 2024 · Background In the CLEAR (Cholesterol Lowering via Bempedoic Acid, an ACL-Inhibiting Regimen) Outcomes trial, treatment of statin-intolerant patients with bempedoic acid produced a …

Nov 14, 2023 · Bempedoic acid (BA), an ATP citrate lyase inhibitor, decreases hepatic generation of cholesterol, upregulates low-density lipoprotein (LDL) receptor expression in the liver, and eventually …

Key Points Question To what extent does bempedoic acid lower low-density lipoprotein cholesterol (LDL-C) levels in patients at high cardiovascular risk who have ongoing hypercholesterolemia, …

Oct 15, 2023 · Bempedoic acid is a selective inhibitor of the adenosine triphosphate citrate lyase that reduces low-density lipoprotein cholesterol (LDLc) levels by 17% to 28%. Although the Evaluation of …

Bempedoic acid interferes with an enzyme in the liver that regulates cholesterol production. It allows for increased clearance of LDL-C from the blood stream leading to lower levels. Bempedoic acid is only …

Nov 26, 2025 · Bempedoic acid is similar with statin therapy at decreasing the risk of a first major vascular event per every 1 mmol/L reduction in LDL-C, according to a post hoc analysis of the …

Aug 26, 2024 · Introduction: Bempedoic acid is a first-in-class low-density lipoprotein cholesterol (LDL-C) lowering agent which offers an important opportunity for further LDL-C lowering in statin-intolerant ...

Mar 1, 2024 · Conclusion Bempedoic acid significantly lowered LDL-C levels vs. placebo and was generally well tolerated in all patients, with no new safety findings in patients with HeFH, despite …