DNA mismatch repair protein Mlh1 or MutL protein homolog 1 is a protein that in humans is encoded by the MLH1 gene located on chromosome 3. The gene is commonly associated with hereditary …

The MLH1 gene provides instructions for making a protein that plays an essential role in repairing DNA. This protein helps correct errors that are made when DNA is copied in preparation for cell division, a …

Jul 12, 2023 · This information explains how having a mutation in the MLH1 gene may affect you and your family. In this resource, the word “family” means people related to you by blood.

Jul 28, 2025 · People with an inherited MLH1 mutation have an increased risk for many cancers, especially of the large intestine (the colon and the rectum) and uterus (endometrium).

MLH1 is a gene that produces a protein involved in DNA repair, specifically in a process called mismatch repair. This protein works closely with other mismatch repair proteins, including PMS2, MSH2, and …

Nov 14, 2025 · MLH1 (MutL Homolog 1) is a Protein Coding gene. Diseases associated with MLH1 include Mismatch Repair Cancer Syndrome 1 and Lynch Syndrome 2. Among its related pathways …

Sep 13, 2025 · MutL_Trans_MLH1; MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1).

The job of the MLH1 gene is to prevent cancer. It is called a tumor suppressor gene. MLH1 is a type of tumor suppressor gene known as a DNA mismatch repair gene. When working correctly, tumor …

Jul 23, 2025 · Understand how an inherited mutation in the MLH1 gene affects the body’s DNA repair process, elevating cancer risks and shaping proactive health strategies.

The mutL homolog 1 (MLH1) gene encodes a protein that functions in the DNA-mismatch repair process. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and …