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med's go on Instagram: "Sildenafil is a highly selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE-5), the enzyme predominantly responsible for the breakdown of cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells → activates guanylate cyclase → increases cGMP → smooth muscle relaxation and penile arterial inflow. By inhibiting PDE-5, sildenafil markedly prolongs the action
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